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Physical effects
Stimulation - In terms of its effects on the user's physical energy levels, α-PVP can be considered to be extremely stimulating and energetic. This encourages activities such as running, climbing and dancing, although it can also encourage just sitting immobile engaged in repetitive tasks. The particular style of stimulation which α-PVP presents can be described as forced. This means that at higher dosages it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes and vibrations become present, resulting in an extreme unsteadiness of the hands and a general lack of motor control.
Vibrating vision - A person's eyeballs may begin to spontaneously wiggle back and forth in a rapid motion, causing vision to become blurry and temporarily out of focus-- a condition known as nystagmus.
Appetite suppression
Visual acuity suppression - α-PVP can have visual and vision-impairing effects that can lend readily to peripheral hallucinations.
Focus enhancement - α-PVP has been noted as enhancing focus, but in a way that leaves the user totally fixated on whatever task at hand, however trivial.
Sublingual numbing - In a similar fashion to that of cocaine this compound numbs the areas of the body which it touches, these areas can include the nostrils, gums, mouth and urethra of the user.
Negative physical side effects
Abnormal heartbeat - Due to the potency of its rush, α-PVP can cause various uncomfortable or painful sensations in the heart, especially when abused or used for extended periods. Those with genetic a family history of heart issues are discouraged from using this drug in its most potent methods of administration, if not avoid it entirely.
Dehydration - Dry mouth and dehydration are a universal experience with α-PVP and are a product of an increased heart rate, adrenergic activity and the motivation to engage in strenuous physical activities. While it is important to avoid becoming dehydrated, especially when out dancing in a hot environment, there is a potential possibility of suffering from water intoxication through over-drinking. Therefore it is advised that users simply sip at water and be mindful of their water in-take.
Increased heart rate
Decreased heart rate - Although sympathomimetic cathinones like α-PVP typically raise one's heart rate and blood-pressure, it is possible to experience the reverse, sometimes triggering sudden fainting spells. While the cause is not yet well understood, it seems this happens less commonly in healthy individuals .
Difficulty urinating - Higher doses of α-PVP result in an overall difficulty when it comes to urination, an effect that is temporary and typically harmless.
Headaches - This typically can occur towards the end of the experience, but can sometimes happen during one as well.
Increased blood pressure - α-PVP, especially when it is vaporized or injected, can lead to sudden spikes of blood pressure that may manifest in an extremely uncomfortable "exploding heart" sensation.
Increased perspiration
Muscle spasms
Restless leg syndrome
Vasoconstriction - α-PVP can be considered very vasoconstricting at higher doses, and is on par with that of amphetamine and methamphetamine.
Teeth grinding - This component can be considered to be less intense when compared with that of MDMA, though becomes more present at high doses.
Seizure - α-PVP may lower the seizure threshold in some individuals, especially when it is abused.
Cognitive effects
The cognitive effects of α-PVP can be broken down into several components which progressively intensify proportional to dosage. The ample head space of α-PVP is described by many as one of extreme mental stimulation and a powerful rushing euphoria. It contains a large number of typical stimulant cognitive effects, particularly those of the cathinone or pyrovalerone classes of drugs.
The most prominent of these cognitive effects generally include:
Analysis enhancement - Users report that this effect typically only occurs at low doses, and becomes increasingly more impairing as one increases their intake.
Euphoria - A euphoria very similar to amphetamine or cocaine is present as well as feelings of joy and happiness which are likely a direct result of serotonin and dopamine release.
Ego inflation - Similar to the ego inflation of cocaine or methamphetamine, α-PVP can temporarily induce states of egomania at its peak.
Compulsive redosing - A high tendency to compulsive redose is a hallmark of this class of drug.
Disinhibition
Immersion enhancement
Increased libido - α-PVP, like its predecessor α-PVP can induce states of extreme sexual arousal due to its powerful disinhibiting effects
Increased music appreciation
Motivation enhancement - This effect provides short-lived states of extreme motivation, but due to the cognitively narrowing aspects of its action, rarely ever translates into productive action.
Thought acceleration
Time distortion - Strong feelings of time compression are common within α-PVP and increase in the perception of perceived experience is greatly increased
Wakefulness
Feelings of impending doom - This typically is experienced when the drug is abused, but can happen at higher than needed doses, or the comedowns of binges. It can also happen spontaneously, although this tends to be rare.
Paranoia - α-PVP can lead to states of extreme paranoia when abused or dosed too highly, which is why eyeballing this substance is strongly discouraged. The paranoia this compound produces shares many features of the paranoia that can be induced by methamphetamine or cocaine, and typically happens while coming down.
Psychosis - This compound is known to readily induce psychosis if it is abused for prolonged periods of time.
Tactile effects
Tactile enhancement - α-PVP can enhance one's sense of touch to extreme degrees, often leading to states of sexual arousal.
Spontaneous tactile sensations - The "body high" of α-PVP can be described as a moderate to extreme euphoric tingling sensation that encompasses the entire body. It is capable of becoming overwhelming at higher dosages. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
Visual effects
Brightness alteration - α-PVP can make spaces seem brighter due to its ability to dilate the pupils.
Drifting - This effect is usually very mild and increases with sleep deprivation.
Visual acuity suppression
Hallucinatory states
Peripheral information misinterpretation
Scenarios and plots
Auditory effects
Auditory distortion
Auditory hallucinations
After effects
The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:
Anxiety
Appetite suppression
Cognitive fatigue
Depression
Dream potentiation - Some users note extremely strange and sometimes rather scary dreams for several nights after taking large doses of MDMA.
Sleep paralysis - Some users note sleep paralysis after consuming MDMA.
Irritability
Motivation suppression
Thought deceleration
Wakefulness
Experience reports
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Erowid Experience Vaults: A-PVP
Toxicity and harm potential
Main article: Research chemicals § Toxicity and harm potential
The toxicity and long-term health effects of recreational α-PVP use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because α-PVP has very little history of human usage. Anecdotal evidence from people who have tried α-PVP within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
α-PVP has been reported to be the cause, or a significant contributory cause, of death in suicides and overdoses caused by combinations of drugs.[2][3][4][5] α-PVP has also been linked to at least one death where it was combined with pentedrone and caused heart failure.[6]
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
As with other stimulants, the chronic use of α-PVP can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of α-PVP develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). α-PVP presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of α-PVP all stimulants will have a reduced effect.
Psychosis
Main article: Stimulant psychosis
α-PVP, like other stimulants, can result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions).[7][8] A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely.[9][10] The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis.[11]
This post has been edited by hennessy on 10 Jan 2017, 17:27