Miryamაჰა ,ეს შენ თვითონ მოთარგმნე:His medical history was significant
for mild asthma, for which he was on no medications.
ახლა თვითონ თემის სათაური თარგმნე:Cerebellar Infarction in Adolescent Males Associated With
Acute Marijuana Use
Thomas Geller, MD*‡; Laura Loftis, MD‡; and David
ახლა ეს მოთარგმნე:CONCLUSIONS
From the literature, it is clear that marijuana use
can cause systemic hypotension, impair peripheral
vasomotor reflexes, and may alter central nervous
system blood flow and cerebral vascular autoregulation.
Marijuana use has been associated with stroke
in adults, but acute central nervous system infarction
related to marijuana use is not well described in
children. Although the mechanism of neurologic injury
and its localization to the posterior circulation in
these cases remains uncertain, our observation of
acute cerebellar infarction in 3 adolescents shortly
after marijuana use suggests that this drug may contribute
to cerebellar vascular injury, possibly by
causing vasospasm, especially in the inexperienced
or episodic user, resulting in cerebellar ischemia. The
cerebellum may be more susceptible to ischemia,
because it is a region without rich collateral circulation.
Alternative explanations for ischemic stroke include
contamination of marijuana with other substances
(unlikely in that the 3 cases we have seen
occurred over a 5-year period) and random cerebellar
strokes coincident with but unrelated to marijuana
use (unlikely given the similarities of our 3
cases in presentation, history, age, gender, and
pathologic findings).
Early recognition of cerebellar stroke is essential
for prompt neurosurgical intervention to prevent lethal
brainstem functional compromise by relieving
cerebellar edema. The literature indicates that the
mortality rate in cerebellar stroke dramatically increases
with the interval from presentation to diagnosis.17
If a cerebellar infarction produces a mass
effect with signs of brainstem compression or herniation,
a surgical decompressive procedure may be
necessary in such patients.24,25 Although reported
strokes associated with marijuana use are few, marijuana
use may represent a genuine risk factor for
stroke, especially in the adolescent and particularly
in the cerebellar circulation.
აბა, შენ იცი... მეორე კვლევაზე შემდეგ გადავიდეთ ამას რომ გავაიასნებთ.
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